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Furthermore, a recent meta-analysis of 11 longitudinal cohort studies demonstrated that MASLD is associated with a 1.5-fold higher long-term risk of new-onset heart failure, regardless of the presence of hypertension, T2DM, and other common cardiometabolic risk factors [69]

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This amplifies tissue injury and highlights ferroptosis as a therapeutic target for IRI-related pathologies (40, 41)

In conclusion, these results indicate that VPA-exposed rats avoided social interaction and preferred non-social contexts, reflecting impaired sociability (P 0.05 )